CBD for PainWritten by Justin Ayob and Antonio OrtegaCannabidiol (CBD) is a nonintoxicating Phyto cannabinoid extracted from Cannabis sativa, primarily found in the flowers and leaves of the cannabis plant. Of the many cannabinoids present in Cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol are the two components found at the highest concentrations. In recent years Cannabidiol’s availability has increased as more changes are being made to federal and state regulations across the country. With legislative action taking place, the market for CBD as a sole agent, as opposed to in combination with THC in medical marijuana) is rapidly expanding. CBD marketed products such as gummies, body lotions, oils for oral ingestion, and even cartridges for vaping are now being stocked at pharmacies in many states. The anterolateral system where pain perception and modulation are mediated, include nociceptors that signal and give rise to acute pain. Tissue damage that leads to inflammation mediates chronic pain known as inflammatory nociceptive pain. CBD regulates the endocannabinoid system which is present at essentially all levels of the anterolateral system and seems to play an unknown role in immunoinflammatory responses. As of today, there is not enough clinical data to support CBD as a sole agent in the treatment of pain. According to multiple clinical trials CBD has been shown to be well tolerated in children with seizure disorders, but its safety profile in adults with chronic health conditions remain unknown. Of at least 19 registered clinical trials evaluating CBD’s effect on pain, most have not begun recruiting trial candidates while others have not listed clinical trial results. While CBD continues to grow in popularity in the states and many have reported varying benefits to the use of CBD it is important to remember as pharmacists to inform patients that there is insufficient evidence to knowingly recommend the use of CBD for pain management. References:
· Mlost, Jakub et al. “Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action.” International journal of molecular sciences vol. 21,22 8870. 23 Nov. 2020, doi:10.3390/ijms21228870
· Svensson, Craig K. “CBD for the treatment of pain: What is the evidence?.” Journal of the American Pharmacists Association : JAPhAvol. 60,6 (2020): e80-e83. doi:10.1016/j.japh.2020.06.009
CBD for Pain Written by Justin Ayob and Antonio Ortega Cannabidiol (CBD) is a nonintoxicating Phyto cannabinoid extracted from Cannabis sativa, primarily found in the flowers and leaves of the cannabis plant. Of the many cannabinoids present in Cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol are the two components found at the highest concentrations. In recent years Cannabidiol’s availability has increased as more changes are being made to federal and state regulations across the country. With legislative action taking place, the market for CBD as a sole agent, as opposed to in combination with THC in medical marijuana) is rapidly expanding. CBD marketed products such as gummies, body lotions, oils for oral ingestion, and even cartridges for vaping are now being stocked at pharmacies in many states. The anterolateral system where pain perception and modulation are mediated, include nociceptors that signal and give rise to acute pain. Tissue damage that leads to inflammation mediates chronic pain known as inflammatory nociceptive pain. CBD regulates the endocannabinoid system which is present at essentially all levels of the anterolateral system and seems to play an unknown role in immunoinflammatory responses. As of today, there is not enough clinical data to support CBD as a sole agent in the treatment of pain. According to multiple clinical trials CBD has been shown to be well tolerated in children with seizure disorders, but its safety profile in adults with chronic health conditions remain unknown. Of at least 19 registered clinical trials evaluating CBD’s effect on pain, most have not begun recruiting trial candidates while others have not listed clinical trial results. While CBD continues to grow in popularity in the states and many have reported varying benefits to the use of CBD it is important to remember as pharmacists to inform patients that there is insufficient evidence to knowingly recommend the use of CBD for pain management. References:
· Mlost, Jakub et al. “Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action.” International journal of molecular sciences vol. 21,22 8870. 23 Nov. 2020, doi:10.3390/ijms21228870
· Svensson, Craig K. “CBD for the treatment of pain: What is the evidence?.” Journal of the American Pharmacists Association : JAPhAvol. 60,6 (2020): e80-e83. doi:10.1016/j.japh.2020.06.009